A new paper published in Nature by Gilad Evrony and colleagues introduces HiDEF-seq, a single-molecule DNA sequencing method that can identify single-strand DNA damage and mismatches. This innovative approach, based on HiFi sequencing, has significant implications for understanding how mutations occur, particularly in cancer and aging. The research reveals DNA mismatch and damage patterns, providing insights into the strand-resolved mutagenicity of DNA damage and repair. The study highlights single-strand changes and offers a detailed analysis of strand-resolved mutagenicity.
Congratulations to @giladevrony and team on their @Nature publication of the HIDEF-seq method for detecting somatic mutations. This groundbreaking work, based on #HiFisequencing, will advance studies of how mutations occur, particularly in cancer and aging. https://t.co/d2d0h4E02a
Congratulations to @giladevrony and team on their Nature publication of the HIDEF-seq method for detecting somatic mutations. This groundbreaking work, based on #HiFisequencing, will advance studies of how mutations occur, particularly in cancer and aging. https://t.co/d2d0h4E02a
Nature research paper: Strand-resolved mutagenicity of DNA damage and repair https://t.co/eO9MJFA7Ni
DNA mismatch and damage patterns revealed by single-molecule sequencing. #DNAmismatch #DNAdamage #SingleMoleculeSequencing #SMRT #HiFi @PacBio #Sequencing @giladevrony @Nature https://t.co/lEEbpEfF1e
Now out @Nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)! https://t.co/4dPi0CpiAl
Nature research paper: DNA mismatch and damage patterns revealed by single-molecule sequencing https://t.co/Xfd1BKuCLd
Also in @Nature today - @giladevrony and colleagues publish HiDEF-seq a single molecule sequencing approach that can identify single strand DNA damage that precede DNA mutations. Fascinating! https://t.co/C93sMtASjx
🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair https://t.co/VTP3h139Q4 Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]