Researchers at Arc Institute, in collaboration with partner universities, have discovered bridge RNAs enabling modular DNA modifications. The findings include RNA-guided recombinase enzymes for genome editing and widespread RNA-guided RNA modification in various organisms.
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This paper out just 2 days ago is making a big splash! From @pdhsu and team: “Bridge RNAs direct programmable recombination of target and donor DNA.” Thank you for choosing Twist Oligo Pools to support this work! 🧬 https://t.co/7iZV08IBKP
Come Together: Bridge RNAs Close the Gap to Genome Design Arc Institute researchers have discovered an RNA-guided system that enables modular and programmable DNA insertions, excisions, and inversions. Learn more: https://t.co/yh1s7ves22 https://t.co/i7Dse99d3n
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Did you see the bridge RNA papers yesterday? Bacterial transposons promote programmable, RNA-guided DNA recombination. Remarkably, we found that the recombinase was co-opted in archaea and eukaryotes for widspread RNA-guided RNA modification, an essential function in humans! https://t.co/dsaFFQ48r3
News & Views: Two @Nature papers report on the discovery of RNA-guided recombinase enzymes, which herald a new chapter for genome editing—enabling the insertion, inversion or deletion of long DNA sequences at user-specified genome positions. 🔒 https://t.co/4bQen1FUMV
"This was a 2+ year detective story uniquely enabled by the @arcinstitute model, blending Arc's technical staff, PhD students from our partner universities, and hybrid computational & experimental science." See thread below on discovery of bridge RNAs & a new mechanism for… https://t.co/qhiGFq2pAt