Researchers from the Arc Institute have introduced a groundbreaking genome engineering technology known as bridge RNA-guided DNA recombination. This new mechanism, detailed in two papers published in Nature, allows for the programmable insertion, excision, or inversion of DNA sequences. Unlike CRISPR, bridge RNA-guided DNA recombination does not rely on cellular repair mechanisms, potentially making it safer and more precise. The discovery includes three atomic structures of the first natural RNA-guided recombinase, which enhances the power and precision of genome editing for long DNA sequences. This modular system involves the IS110 recombinase and non-coding RNA, significantly reshaping animal and plant genomes.
We aim to provide useful computational tools so folks can hit the ground running with bridge recombinases! Bridge RNAs are a bit more complicated than CRISPR guides, so here's a simple bridge RNA guide designer, your feedback is welcome: https://t.co/aLD7OS9HFd
Bridge RNA-guided DNA recombination differs from CRISPR by not relying on cellular repair mechanisms, making it potentially safer and more programmable for precise genome editing. https://t.co/5XqLAZbyjU
Programmable DNA Rearrangement via IS110 Non-Coding RNA IS110 circular form drives expression of a non-coding RNA (ncRNA) with two binding loops that recognize the IS110 DNA donor and its genomic target site, facilitating DNA recombination by the IS110 recombinase. Each binding…
Patrick manages to capture both the magic of AI and Bridge DNA editing in one tweet. We live in such an incredible time. https://t.co/DGDyqTnm61
Nature research paper: Structural mechanism of bridge RNA-guided recombination https://t.co/8WhcPKMDut
CRISPR gene editing has revolutionised biology, but now an even more powerful technique called bridge editing could let us completely reshape animal and plant genomes. https://t.co/lqDXMT0z4o
This morning, Nature published two papers on bridge editing, the new genome engineering technology from @ArcInstitute: https://t.co/gxaeSiDfJr, https://t.co/uQu05rFrmN. I'm quite excited about its potential! Since the whole thing is pretty arcane, I fed the blog post…
New @Nature Bridge RNA: a big discovery form nature that adds to power and precision of genome editing for long DNA sequences https://t.co/DxKNSGoFZe https://t.co/PaiJ3mQhgn https://t.co/vDJUUFgDlW @pdhsu @arcinstitute @hnisimasu @mgdurrant @SKonermann @johnmcspeedy @AprilPawluk… https://t.co/7x62mUHmYk
Come Together: Bridge RNAs Close the Gap to Genome Design Arc Institute researchers have discovered an RNA-guided system that enables modular and programmable DNA insertions, excisions, and inversions. Learn more: https://t.co/yh1s7ves22 https://t.co/0xqWh6Uu7d
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design https://t.co/7l5XHNXhbH
🧬Introducing a powerful, programmable new mechanism for genome design: DNA recombination with bridge RNAs. As the first natural RNA-guided DNA recombinase, this system enables insertion, excision, or inversion of any two DNA sequences. Out today in @Nature, led by Arc… https://t.co/JWWOJcu2en