Recent studies published in Cell Press and Nature have uncovered groundbreaking findings in the field of neuroscience, specifically regarding the immune capabilities of non-immune brain cells. Researchers, including Joe Luquette in collaboration with Chris A. Walsh's lab, have demonstrated the age-associated accumulation of mutations in various cell types, including neurons and oligodendrocytes, and explored their mechanisms and genomic locations. Another pivotal discovery involves astrocytes, central nervous system cells traditionally not associated with immune functions, which have been found to develop what is termed as 'immune memory.' This capability, described as 'Disease-associated astrocyte epigenetic memory,' might play a significant role in driving central nervous system pathologies, such as multiple sclerosis, according to studies published in @CellCellPress and mentioned by @BrighamWomens. These findings not only challenge the existing understanding of cellular roles within the brain but also open new avenues for understanding and potentially treating neuroinflammatory diseases.
Nature research paper: Disease-associated astrocyte epigenetic memory promotes CNS pathology https://t.co/mZUkmttV1n
Astrocytes Remember: A New Layer of Immune Memory Uncovered Researchers have made a pioneering discovery that astrocytes, cells within the central nervous system traditionally not associated with immune functions, are capable of developing what's being called an "immune memory."… https://t.co/UAMn6GgKEa
Study finds non-immune brain cells can acquire immune memory, may drive CNS pathologies like multiple sclerosis @BrighamWomens https://t.co/mpLyML7X3V
Inflammatory memory in non-immune CNS-resident and non-neuronal cells.l 🤔 v cool stuff! https://t.co/aiNs5g0WYg
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology. @CellCellPress https://t.co/p6tIxUFXBg https://t.co/GKIfGXEjmF
We've previously demonstrated age-associated accumulation of mutations in neurons. What about in other cell types, such as oligodendrocytes? By what mechanism & where in the genome? Out today in @CellCellPress Analysis by Joe Luquette in collaboration with @ChrisAWalsh1 lab [1/] https://t.co/0CqKwHsvX7