Recent research has highlighted the significant role of microglia in Alzheimer's disease and brain aging. A study published in Cell reveals that microglial-derived C1q integrates into neuronal ribonucleoprotein complexes, impacting protein homeostasis in the aging brain. Additionally, selective suppression of oligodendrocyte-derived amyloid beta has been shown to rescue neuronal dysfunction in Alzheimer's disease. Another study indicates that in a mouse model of Alzheimer's, amyloidosis triggers age-related oligodendrocyte and myelin damage mediated by CD8+ T cells, promoting the accumulation of interferon-activated myelin-damaging microglia. Furthermore, microglial activation by T cells has been linked to myelin pathology in amyloidosis. These findings underscore the complex interactions between microglia, neurons, and immune cells in neurodegenerative diseases.
Causal Cortical and Thalamic Connections in the Human Brain https://t.co/kQQQzWmmr2 #biorxiv_neursci
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis @NatureNeuro https://t.co/m1paBdcLSR
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain: Cell https://t.co/Ye9XQqQ4lF
Excited to share our recent work in @cellcellpress: Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain: Cell https://t.co/7RkpnE7TXT @stevens1lab 1/n
We are excited to share new paper led by the talented @NicoleScottHew1 that a microglial C1q, can be internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3 https://t.co/FC7Ef7ZEMg
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress https://t.co/E7dqyLYoty https://t.co/Wwe2FBpYWO
In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia https://t.co/StqjJbezAX
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's Disease https://t.co/VmkJLcIjdo #biorxiv_neursci
Retinal microglial cells increase expression and release of IL-1β when exposed to ATP https://t.co/oDNdBwDQNw #biorxiv_neursci
Single-nucleus RNA sequencing of striatal microglia reveals distinct transcriptomic signatures of acute stress and chronic exercise https://t.co/viYOvqohJk #biorxiv_neursci
CD11c-expressing microglia are transient, driven by interactions with apoptotic cells https://t.co/7BhGic1m4y #biorxiv_neursci
A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex https://t.co/u5StiKlo7k #biorxiv_neursci
The Alzheimer's disease gene SORL1 regulates lysosome function in human microglia https://t.co/Xo7todtVMb #biorxiv_neursci