Recent studies, including work by Cappelluti et al. published in Nature, have demonstrated a significant advancement in the field of genetics, focusing on a technique known as 'hit-and-run epigenome editing'. This method, highlighted in a series of tweets from various scientific sources, offers a promising alternative to traditional genome editing by efficiently and permanently silencing genes without altering the DNA sequence. Specifically, the technique has been applied to the PCSK9 gene, which plays a crucial role in regulating cholesterol levels. The research, conducted on mice, showed marked and prolonged lowering of LDL cholesterol levels through the use of mRNA-nanoparticle packages, without the need for permanent genome editing. This breakthrough could pave the way for new treatments for cholesterol-related conditions, offering a potentially safer and more durable solution than current methods.
$SGMO though #epigenetic editing gets around having to cleave ANY DNA strand (genotoxic stress, recombination risk)... ...I believe the real selling point is when the field can show gene-specific reversibility with a readily administered molecule.
$SGMO as we celebrate today zinc fingers as the most versatile (and likely immunogenically silent) (epi)genome platform... ...stock now also in compliance with $1.00 closing bid requirement.🥂
$SGMO as we celebrate today zinc fingers as the most versatile (and likely immunogenically silent) (epi)genome platform... ...stock now also in compliance with $1.00 closing bid requirement.
$SGMO MOVE OVER, #CRISPR and #genomeediting, here comes permanent (--> CpG) #epigenome editing. Zinc 🫵 finger beats both CRISPR and TALEs. @nature publishes In vivo persistence demonstrated in forced liver regeneration experiment. No bacterial protein needed. #PCSK9 $VERV… https://t.co/fnVQmSwpqR
Latest from the Nature Podcast 🔊 Could this one-time ‘epigenetic’ treatment control cholesterol? https://t.co/yTlhpx51Z3
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing https://t.co/rsF1JzoCvG https://t.co/mW3hXLgTCj
'Epigenetic' editing cuts cholesterol in mice https://t.co/5VicvaemhT https://t.co/2Jof402I4g
Efficient and permanent silencing of genes without altering the DNA sequence using "hit-and-run epigenome editing" 🔥 A new work in Nature by Cappelluti et al. reports a successful, lifelong in vivo epigenetic silencing of PCSK9 in mice. wow https://t.co/3Q3CVJVFZI
An alternative to genome editing can reduce the activity of a gene that affects cholesterol levels without changing the DNA sequence https://t.co/wANkyun4rD
Nature research paper: Durable and efficient gene silencing in vivo by hit-and-run epigenome editing https://t.co/8ri1iiNKxP
🧬Epigenetic Editing @chromamedicine out with 🔥 Durable and efficient gene silencing in vivo by hit-and-run epigenome editing https://t.co/md1OfvpDtY https://t.co/lmuHRqCzEg
A mouse study in @Nature demonstrates durable repression of a gene that has a role in controlling cholesterol levels, achieved without permanent genome editing. https://t.co/mAF1c5Wrzm https://t.co/UVU1BhrQE3
"Hit and run" one shot epigenetic silencing of the PCSK9 cholesterol gene with marked and prolonged LDL lowering https://t.co/5gU6zw1SXt —using mRNA-nanoparticle package —potential alternative to DNA base editing @Nature @justsaysinmice https://t.co/1EmNP3bLEN