Recent studies have highlighted a groundbreaking approach to harnessing the benefits of glucocorticoids while minimizing their notorious side effects. Researchers have discovered a new strategy that focuses on metabolic rewiring to promote the anti-inflammatory effects of these drugs. This innovative method involves the modulation of mitochondrial metabolism and the tricarboxylic acid (TCA) cycle flux, which leads to a reduction in inflammation. Specifically, the research, published in Nature and featured in Science Magazine, reveals that glucocorticoids exert their anti-inflammatory actions not through the expected transcriptional pathways but by enhancing the Krebs cycle in macrophages. This process results in increased production of itaconate, a metabolite that interferes with the induction of pro-inflammatory cytokines. This significant finding, a result of collaboration among leading scientists, including those from Krönke Lab, opens new avenues for the development of glucocorticoid therapies with fewer side effects. The study was highlighted by Krönke & co and mentioned by @RealKroenkeLab, with significant findings published in @Nature and featured in @ScienceMagazine.
Nature research paper: Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids https://t.co/Si8kw31MmQ
#MysterySolved! Krönke &co show @Nature that glucocorticoids are anti-inflammatory not in a transcriptional manner (🤯), but by boosting the Krebs cycle in macrophages, driving excessive #itaconate that interferes with pro-inflammatory cytokine induction! https://t.co/P96x4kzbbe
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids | Nature - one of our favorite collaboration partners and by now also my friend-mentor @RealKroenkeLab just decoded the mode of action of glucocorticoids! https://t.co/KhpfN0qBkx
Molecular mechanisms by which glucocorticoids rewire mitochondrial metabolism and TCA cycle flux, thereby reducing #inflammation @Nature https://t.co/nGD2l1fo1S
"Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids" https://t.co/vdSy16qI8W
Glucocorticoids are powerful drugs—sometimes too powerful, as they're notorious for their side effects. A new strategy aims to focus that power. That study and more of the best from @ScienceMagazine and science in today's #ScienceAdviser https://t.co/rSTVdvQbWC https://t.co/yPdldS980y