Researchers have published findings in @Nature on the exploration of the soluble protein universe and the design of functional soluble membrane proteins. Computational design is being used to create soluble and functional membrane protein analogues, addressing challenges in drug screening due to unstable proteins. The approach shows promise in drug design and protein synthesis, with potential to accelerate drug discovery.
Nature research paper: Computational design of soluble and functional membrane protein analogues https://t.co/ttKaAGvRvI
Membrane protein analogs could accelerate drug discovery @epfl_en @nature https://t.co/6th2tA9y2v
🤖 The issue is with agonist more potency is often not better - need to hit it just right - Goldilocks. Nevertheless, computational design seems to be making rapid progress in drug design / protein synthesis https://t.co/C2zdTWTib6
😌PROBLEM: Membrane proteins such as GPCRs are challenging to drug bc we cannot stabilize the proteins/domains to screen drug libraries against. (i.e., it’s a protein production problem) 🤖SOLUTION: Computational design of soluble and functional membrane protein analogues If… https://t.co/BoqwGMgyCp
😌PROBLEM: Membrane proteins such as GPCR are challenging to drug bc we cannot stabilize the proteins/domains to screen drug libraries again. (i.e., it’s a protein production problem) 🤖SOLUTION: Computational design of soluble and functional membrane protein analogues If you… https://t.co/DlGMV2VN0H
Computational design of soluble and functional membrane protein analogues #machinelearning #compchem https://t.co/JHViOmEu9Z
Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6 https://t.co/Dakeh8Hyw7 https://t.co/bxxbP1QBkN