Recent studies have highlighted a significant breakthrough in understanding how early-stage cancer cells evade the immune system. Researchers at MIT, in collaboration with Harvard Medical School, have discovered that colorectal cancer cells in their initial stages recruit the SOX17 gene, making them virtually invisible to the immune system. This discovery was further supported by findings from a team including Postdoctoral Fellow Nori Goto and DFCI collaborator Judith Agudo, demonstrating how the earliest premalignant intestinal stem cells avoid immune detection. The studies, published in Nature, the Journal of Experimental Medicine, and the National Immunology, indicate a potential new direction in cancer treatment, focusing on the immune system's ability to detect and fight cancer.
How early-stage cancer cells hide from the immune system: A new study finds precancerous colon cells turn on a gene called SOX17, which helps them evade detection and develop into more advanced tumors. https://t.co/0pJxS266YY https://t.co/Zrol9hnhOZ
Colon Cancer Traced to Cells That Activate Immune-Escape Genes Scientists have found that early-stage colorectal cancer cells recruit the SOX17 gene to essentially become invisible to the immune system. Learn more: https://t.co/q2HKQCjnk4 https://t.co/0oISmKfVMi
Researcher discusses turbocharging #CRISPR to understand how the immune system fights cancer @harvardmed @natimmunol @JExpMed https://t.co/LbDPeTGTrt
https://t.co/xOEU9GjEhM Great teamwork from amazing Post doctoral fellow Nori Goto and our wonderful DFCI collaborator @JudithAgudo1 showing how the earliest premalignant intestinal stem cell evade immune detection. @MITBiology @kochinstitute @DanaFarber @BIDMCpath @MGHPathology…
How early-stage #cancer cells hide from the #immuneSystem @MIT @nature https://t.co/aoXRkbSSy3