Recent studies have shown that certain neurons in the brain, particularly in neurodegenerative diseases like Alzheimer's and Parkinson's, can re-enter the cell cycle and quickly become senescent, leading to neurodegeneration. Researchers have utilized bioinformatics and single-nucleus RNA sequencing to characterize these neurons in both healthy aging and diseased human brains.
Brain neurons re-entering the cell cycle age quickly and shift to senescence, particularly in neurodegenerative disease https://t.co/KD8jiVoUWh via @PLOSBiology #Alzheimers #dementia #health #biology #science https://t.co/BDYze685Hk
Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence https://t.co/alVxvSenMH
Neuronal cell cycle reentry events in the aging #brain are more prevalent in neurodegeneration and lead to cellular senescence https://t.co/WRvDefCaAk @PLOSBiology https://t.co/K1OO8rt55m
DYK? These fish 🐠🧠 can help scientists understand how aging increases risk for neurodegenerative diseases. @LarsMSteinmetz, @AOri_lab, Michael Ward + Hemali Phatnani study how proteins move around inside cells & how aging & genetics change that in neurodegenerative diseases https://t.co/OCKce2q31D
Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this cell cycle re-entry and accumulation of resulting senescent neurons is more common in Alzheimer’s disease brain than in the normal brain. Learn more: https://t.co/xWihJ5smnI https://t.co/9Lc9WC52P5
"Neurons in #AlzheimersDisease patients tend to re-enter the cell cycle and quickly progress to senescence. Using advanced snRNA-seq techniques, Kim Hei-Man Chow, et al. analyzed over 30,000 nuclei to track these changes." Learn More @PLOSBiology https://t.co/lGXko3gPcS https://t.co/tMPjOJnFWN
Alzheimer's Disease Neurons Reenter Cell Cycle, Become Senescent Senescent cells displayed more proinflammatory, metabolically deregulated, and pathology-associated signatures. Learn more: https://t.co/xWihJ5smnI
Cell cycle genes are re-activated in some #neurons as our brains age. @chow_heiman &co use bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology https://t.co/4g5JKpTDfe https://t.co/StYykmdpWI
Cell cycle genes are re-activated in some #neurons as our brains age. This study uses bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology https://t.co/4g5JKpTDfe https://t.co/zhlYTHaBrj
Cycle of Decline: Neuron Aging in Alzheimer’s Unraveled Researchers discovered a crucial aspect of neuron behavior in Alzheimer's disease, showing that neurons that re-enter the cell cycle are prone to rapid senescence. The study utilized single-nucleus RNA sequencing… https://t.co/Xuyqv6MWMC
Most brain cells have lost their ability to divide. But the ones that can divide (get into cell cycle) — are more frequent in people with Alzheimer's and Parkinson's—quickly become senescent and die, and may contribute to neurodegeneration https://t.co/IWwOEbpdP3 @PLOSBiology https://t.co/JPCNiy4t3F
Brain neurons re-entering the #cellCycle age quickly and shift to senescence, particularly in neurodegenerative disease @plos @PLOSBiology https://t.co/pHMn01FVqx