Recent research has unveiled significant findings in the field of cancer biology, particularly concerning colorectal cancer (CRC) and its association with specific bacteria. A team from Fred Hutchinson Cancer Research Center, including researchers Bullman and @CJohnstonLab1, published a study in Nature identifying a 'high-risk' clade of Fusobacterium nucleatum that is prevalent in the CRC niche. This discovery builds on previous suspicions about the bacterium's link to CRC growth. In related research, a novel technology named BASEHIT was developed to map interactions between commensal microbes and the human exoproteome, shedding light on how microbes interact with the host at a molecular level. Additionally, a separate study highlighted somatic mutations in the normal stomach, revealing hypermutant glands, recurrent somatic trisomies, and a unique landscape of driver mutations. Huge congrats to the amazing first author @mzepedar and the incredible team.
A new study from Bullman and @CJohnstonLab1 @fredhutch out today @Nature. We identify a 'high-risk' clade of F. nucleatum that dominates the human CRC niche. Huge congrats to the amazing first author @mzepedar and the incredible team. 🧵 from Chris 👇 https://t.co/IO9RGK6365 https://t.co/KYZkEIp0LO
A new type of bacteria was found in 50% of colon cancers. Many were aggressive cases. https://t.co/IzjdQdSzAC via @nbcnews Scientists have suspected a link between the bacteria 👇 called Fusobacterium nucleatum, and colorectal cancer growth for almost a decade @DrIanWeissman
.@fredhutch researchers have found that a specific subtype of a bacterium commonly found in the mouth is able to travel to the gut and grow within #colorectalcancer tumors. Learn more: https://t.co/73v3L7cmDA
Ever wonder how microbes interact with the host at a molecular level? Check out our latest paper in @nature with Noah Palm and @chuttenh where we developed a host:microbe profiling technology, BASEHIT, to atlas interactions between commensal microbes and the human exoproteome.…
Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! https://t.co/AcSeFdu53c