Recent research has made significant strides in understanding the genetic factors behind age-related blood cell mutations. A study involving over 200,000 participants from the UK Biobank identified 17 additional genes that drive these mutations, which are linked to clonal haematopoiesis. This process is associated with ageing and increased risks of blood cancers and cardiovascular disease. The findings, published in Nature Genetics, highlight a larger pool of genes involved in these mutations than previously thought. Researchers from institutions including Harvard Medical School and the Sanger Institute, with support from an AFAR grant and the Hevolution Foundation, are contributing to this growing body of knowledge.
Our latest paper out @NatureGenet today. Even more mutated genes driving clonal expansions in blood as we age. Additional genes found in @UKBIOBANK confirmed in >10,000 while genomes of blood cell colonies. @calico @sangerinstitute @SCICambridge @doctor_msc https://t.co/8M14qvDplA
Seventeen More Genes Identified That Drive Age-Related Mutations in Blood Cells New research has identified 17 additional genes that drive the age-related mutations leading to abnormal overgrowth of blood cells. Read more: https://t.co/H6KRA2uHPU https://t.co/JbKOCK4O1h
Blood mutations in >200,000 people @uk_biobank tell us more about risk of multiple diseases and aging process https://t.co/a9qc89FOEv @NatureGenet
New research identifies a larger pool of genes involved in age-related blood cell mutations than previously thought @NatureGenet https://t.co/5u9S0QzxZM
Genes driving the growth of mutated blood cells have been identified 🩸 The research sheds light on factors behind clonal haematopoiesis – a process linked to ageing and increased risks of blood cancers and cardiovascular disease 📈 https://t.co/j2IfIeict7
'I'm a longevity researcher and I swear by this diet to reverse the ageing process and live longer' https://t.co/8vIL56kimz
Through a @Hevolution_f and AFAR grant, @jgooten, of @harvardmed will research "Discovery and manipulation of transcription factors stem cell rejuvenation in aged bone-marrow." Learn more here: https://t.co/X57ITYhaV5 #immuneresponse #immunedysfunction #CellularSenescence https://t.co/UVkOaHpmb8
Hacking the immune system could slow ageing — here’s how https://t.co/wKh5JfSti1
Tried something new in our undergraduate Biology of Aging class this year. Students created YouTube videos in which they analyzed scientific literature related to healthspan/longevity-related interventions. Feel free to check them out here: https://t.co/elBcFYY0EB https://t.co/JqKpB7HfeZ