A new study led by Jackie E. Bader and the Endeavor team at The Mark Foundation has revealed a significant connection between obesity and immune response in cancer. The research, published in Nature, demonstrates that obesity promotes the expression of PD-1 on macrophages, which suppresses anti-tumor immunity. This mechanism, known as the 'obesity paradox,' suggests that while obesity can promote tumor growth, it also sensitizes tumors to checkpoint therapy. The findings offer a new understanding of how obesity affects cancer progression and potential treatment strategies.
Nature research paper: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity https://t.co/rqf1da1aRD
Scientists may finally have an answer for the obesity paradox https://t.co/nXjOR2H416 PD-1 suppresses “immune surveillance” by 👉macrophages and suppresses the killer T cells which in turn allows tumours to grow @DrIanWeissman @pijush357ray @juniorjuri @OGdukeneurosurg https://t.co/1PkeHd2cm6
A(nother) landmark paper from @JeffRathmell laboratory connecting obesity to immunity! Congratulations to the team!! https://t.co/03IRq6vW4v
Cannot express how excited I am that our paper is finally out in real life! Macrophages contribute to the obesity paradox. We found PD-1 acts directly on macrophages to alter metabolism and suppress their anti-tumor function in obesity associated cancers. https://t.co/f3JEB1PhLN
It's out! @JackieEBader led our new @TheMarkFdn Endeavor team study showing obesity promotes PD-1 on macrophages to suppress anti-tumor immunity but sensitize to checkpoint therapy--a new mechanism of the cancer "obesity paradox" @VUMC_VCI @VUMC_Cancer https://t.co/LJiiEalmJv
Excited to announce the inaugural #Obesity #Medicine #JournalClub launched by @tristateobesity 's VP @devika_md and ft. @DrJayyy__ on 6/18 5:30-6:30PM ET Register 👉https://t.co/iky4jkAYMC #free #webinar https://t.co/3EGTcuaO1c