Researchers from MIT and Harvard, in collaboration with the Broad Institute and Whitehead Institute, have developed a new, powerful gene-silencing tool called CHARM. This epigenetic editor shows promise as a therapy against fatal prion diseases by turning off the disease-causing gene. The compact epigenetic editor is small enough to fit into an adeno-associated virus (AAV), which allows it to permeate throughout the brain and effectively silence prions in mice. Chroma Medicine has licensed CHARM for use outside prion disease, paving the way for a new class of genetic approaches to treat certain diseases.
Cool pub alert: Broad scientists built a gene editor that fits into a virus, permeates throughout the brain, and silences prions — in mice, at least. Story by @Jasonmmast : https://t.co/nF4kn7PPpD
Cool story from @leilei_wuu on Broad scientists that made a new, compact #epigenetic editing tool small enough to fit in an #AAV to tackle deadly prion disease. They did such a good job at making it small, the AAV expert told them to add some filler! https://t.co/u7pH4hw7a0
Scientists at @WhiteheadInst and Broad have developed a gene-silencing tool to potentially treat fatal prion diseases by turning off the disease-causing gene. A promising step towards gene therapy for diseases that lack treatments. https://t.co/XcAKv6YPz7 https://t.co/KUUT3P9PJT
Trying to outrun her prion disease, researcher creates powerful epigenetic editor in mice https://t.co/5Zrh1e6TQC
.@JswLab and @broadinstitute collaborators have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, called CHARM, paves the way for a new class of genetic approaches to treat certain diseases: https://t.co/5RjeUkx3J1 https://t.co/ofHF0IOjyY
Trying to outrun her prion disease, researcher creates powerful epigenetic editor in mice By @Jasonmmast https://t.co/VgijF7XzhM
Researchers from MIT and Harvard have crafted a new epigenetic editing tool called CHARM, which they are using to develop a treatment for prion disease + Chroma Medicine has licensed CHARM for use outside prion disease https://t.co/Ss8HEJPadm