A recent study has identified that SARS-CoV-2 selectively targets and accelerates the aging of human pluripotent stem cell-derived dopamine neurons, a process observed in patient autopsies and linked to an increased risk of Parkinson's disease-related symptoms. The senescence response in these neurons, which are susceptible to SARS-CoV-2, can be blunted by three FDA-approved drugs: riluzole, metformin, and imatinib. Researchers emphasize the importance of closely monitoring COVID-19 patients over the coming years for long-term neurological issues such as depression and brain fog. The study's findings are significant given that Parkinson's disease is the second most common neurodegenerative disease.
Parkinson’s disease (PD) is the 2nd most common neurodegenerative disease. In a new Series, authors address the current state of knowledge on epidemiology, recent advances in pathogenesis, & the latest evidence supporting treatment of the disease. 🔗 https://t.co/J82FcyRU0a https://t.co/Fu1R1bEIf7
There may be a link between the SARS-CoV-2 infection of dopaminergic neurons and the long-term effects of COVID-19 symptoms like depression and brain fog, according to new research. Read more: https://t.co/wi6NrmFtJo https://t.co/ApzYJNb3sD
SARS-CoV-2 Infection Can Trigger Dopaminergic Neuron Senescence The study identifies several FDA-approved medications that can stop SARS-CoV-2 infection-induced dopaminergic neuron senescence. Read more: https://t.co/f6VFVIDl38 https://t.co/eNrw3kCgat
"Given our findings, we posit that over the coming years, there is a need to closely monitor COVID-19 patients for an increased risk of developing [Parkinson's-Disease]-related symptoms." https://t.co/YURDLhUpdx
First-ever application of metabolic therapy in ALS (most common form of motor neuron disease), a very difficult neurological disorder with no decent treatment options. This is a (cautiously) encouraging result: https://t.co/NZSQ9sB8AF
A new study shows SARS-CoV-2 infects the brain's dopamine neurons, possibly explaining COVID's long-term neurological issues. Image credit: Liuliu Yang https://t.co/qvF98xUS6V 1/2 https://t.co/aVodjI6SI4
hPSC midbrain DA neurons are susceptible to SARS-CoV2 and undergo senescence response. This is modulated by a-syn, and autopsy data suggest PD relevance. Thanks to @ChenShuibing and the many collaborators - in my lab especially @TaeWanKim0 & @harschnitz. https://t.co/sG2e4k600z
#SARSCoV2 #infection of #dopamine #neurons triggers cellular #senescence response. Authors suggest the need for careful, long-term monitoring of neurological problems in #COVID19 patients. #neuroscience #neurobiology https://t.co/wqGciPhNa1 https://t.co/nVSwqvIOpT
GLP-1 (glucagon-like peptide 1) drugs have already seen enormous success treating obesity and diabetes. We explore how their achievements could be replicated in other illnesses. https://t.co/vnmjdv3AzJ.
“Given our findings, we posit that over the coming years, there is a need to closely monitor COVID-19 patients for an increased risk of developing Parkinson's disease related symptoms.” (The three drugs investigated were riluzole, metformin, and imatinib) https://t.co/lDWB7Esla6
Selective targeting and accelerated aging of dopamine neurons by #SARSCoV2 (derived from human pluripotent stem cells), also seen at patient autopsy, and blunted by metformin and 2 other drugs https://t.co/o1q13SsbTd @liuliuyang1 @ChenShuibing https://t.co/UkV4I6IEa9