Researchers have published a study in Nature where they analyzed 12 million single cells from mouse embryos, tracking development from gastrulation to birth. They observed rapid changes within the first hour after birth, creating a cell type tree from zygote to birth.
Scientists at @uwmnewsroom and @jacksonlab applied a method called optimized #singlecell combinatorial indexing #RNAsequencing (sci-RNA-seq to determine the transcriptional states of cells at two- to six-hour intervals from eight days into... https://t.co/cp4KNLFJt4
#Mouse study finds birth coincides with rapid changes in gene activity @uwmedicine https://t.co/HxdLBVxSm6
ELATUS workflow to uncover biologically important IncRNAs. It started by importing the raw count matrices obtained after preprocessing with both Cell Ranger and Kallisto.
ELATUS, a computational framework based on the pseudoaligner Kallisto that enhances the detection of functional lncRNAs previously undetected and exhibits higher concordance with the ATAC-seq profiles in single-cell multiome data.
ELATUS: Uncovering functional lncRNAs by scRNA-seq https://t.co/5EurrOCNrc https://t.co/3TaWEkVPd0
A single-cell time-lapse of mouse prenatal development from gastrula to birth https://t.co/VTBgn7rfRJ @JShendure https://t.co/zpFODSuz1s
Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: https://t.co/7PsCcqaQS8 https://t.co/bkxfdcZ39L
Excited to share our latest out @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined a cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. https://t.co/7PsCcqaQS8