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The Nobel Prize in Physiology or Medicine for 2023 has been awarded to Katalin Karikó and Drew Weissman for their work that led to the development of mRNA vaccines against COVID-19. Their discoveries concerning nucleoside base modifications enabled the creation of effective mRNA vaccines, which have been administered to billions of people worldwide. Karikó and Weissman's research formed the basis for the Moderna and Pfizer-BioNTech vaccines. Their pioneering technology has the potential to be used in the development of vaccines for other diseases such as the flu and cancer. The award recognizes the transformative impact of mRNA vaccines in combating the pandemic and saving millions of lives.