Recent studies have highlighted the resilience and adaptability of the gut microbiome in the face of antibiotic treatment. A 20-month long study published in Science Translational Medicine found that patients with tuberculosis (TB) undergoing antibiotic treatment had gut bacteria that not only survived the antibiotic onslaught but also evolved resistance mutations, ultimately reestablishing a healthy microbiome. This issue also reported that neutralizing antibodies could protect large animals from HIV-like infections. Another study focused on the gut virome's role in childhood asthma development, considering interactions with host genetics and the bacteriome. Additionally, new research has shed light on how Salmonella can manipulate the host's immune system by inducing IL-1b production to eliminate competing gut microbiota, allowing it to remodel the gut niche for its benefit. Researchers at the Broad Institute uncovered Salmonella mutations that reduce virulence and host immune responses. Moreover, the effectiveness of GLP-1 receptor agonists in reducing systemic inflammation via the central nervous system (CNS) was highlighted, adding to the understanding of microbial interactions and host defenses.
In this week’s Editors’ Choice piece, we highlight the work of Wong and colleagues in @Cell_Metabolism, showing that GLP-1 receptor agonists act in the CNS to reduce systemic inflammation. Read more in this week's issue: https://t.co/pRwP0r16Yc https://t.co/xZEcTSHVcw
Broad researchers uncover Salmonella mutations that reduce virulence and host immune responses, allowing some bacteria to elude the host immune system for years. https://t.co/tnurRLt0J6 https://t.co/V0eS6iXMB8
Researchers have discovered how disease-causing microbes load up their nanoscale needles with just the right proteins to wreak havoc on our cells from the inside. https://t.co/qUWl30m2uk
Commensal bacteria in the gut #microbiome display surprising resilience to #antibiotics, evolve resistance mutations, and reestablish a healthy biome after treatment, shows a 20-month long study of patients with #tuberculosis. @BucciVanni @MichaelGlickma1 https://t.co/rIWW1vYbcE https://t.co/KFo1xE4whI
#Bacteria have an #ImmuneSystem that protects them against #Viruses known as bacteriophages. A research team has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae. @coe_cmfi https://t.co/N1cvsHbqp6
🚨🚨I'm excited to share our new paper out now in @PLOSBiology! We found that Salmonella tricks us into killing its competitors, the gut microbiota, by inducing IL-1b production. This allows Salmonella to remodel the gut niche to it's advantage. A 🧵/1 https://t.co/3o1hPjhfiV
🆒 study on antibiotics and your gut health > take antibiotics for tb > gut bacteria nuked > gut bacteria rebuild *with antibiotic resistance* > rebuilt microbiome now more resilient against anti microbials https://t.co/c5invOj83W
In a recent study, researchers investigated the relationship between early-life #gutvirome and the development of #asthma in childhood while considering the interaction with host genetics and the bacteriome. https://t.co/s0aMte2gu3 Via @NewsMedical
This week's issue of #ScienceTranslationalMedicine is out! A study in tuberculosis patients shows that the gut microbiome is surprisingly resilient to antibiotics, neutralizing antibodies protect large animals from HIV-like infections, and more. https://t.co/es6uVVUMDL https://t.co/mvRV2w36Pm