Deep Visual Proteomics at Single-Cell Resolution Reveals Alpha-1 Antitrypsin Deficiency Mechanisms in Human Liver Published in Nature

Researchers have applied Deep Visual Proteomics (DVP) to study alpha-1 antitrypsin deficiency (AATD), a genetic proteotoxic liver disease, at single-cell resolution in intact human tissue. The work, conducted by scientists at the Pavel Strnad Lab at Uniklinik Aachen, the Alksander Krag Lab at OUH Hospital, and the labs of Mann, was published in Nature. This approach enables detailed mapping of proteotoxic stress in individual hepatocytes, advancing understanding of how liver cells become diseased in AATD. The study builds on prior applications of DVP that have contributed to life-saving medical insights. The research highlights the integration of spatial proteomics with machine learning techniques to dissect complex cellular mechanisms underlying genetic disorders.