Cassava Sciences ($SAVA) is facing significant scrutiny following revelations about its Alzheimer's drug, simufilam. An internal investigation has determined that certain statistical information was potentially used to unblind Dr. Wang during the Phase 2b study, raising concerns about the integrity of the trial data. The September 2020 re-analysis of the Phase 2b biomarker study by Dr. Wang is also unraveling. Additionally, Cassava has confirmed the unblinding in the Phase 2b study and has retracted claims on cognitive endpoints. Two senior employees are under investigation by the Department of Justice (DOJ). Furthermore, the SavaDx assay remains registered as a secondary endpoint for both Phase 3 trials.
Who are the two Senior $SAVA employees they just admitted are under DOJ investigation? https://t.co/RI5ADEouxH
This is very bad for $SAVA and simufilam. The September 2020 "re-do analysis" by Wang of the ph2b biomarker study is unraveling. https://t.co/RsE23y5mwA https://t.co/DFi8D2oj0J
$SAVA Internal Investigation has determined that certain statistical information contained in an attachment to an email sent by a senior employee of Cassava to Dr. Wang before the bioanalysis could have been used to unblind him as to some number of Phase 2b Study participants.
$sava out with an 8k confirming unblinding in P2b and walking back claims on cognitive endpoints… busy ass-covering throwing-under-bus weekend for Remi and crew 😝 https://t.co/MPo3GL2Qiu
btw, $SAVA STILL has Wang's SavaDx assay registered as a secondary endpoint for both of the Ph3 trials (they would have used that to claim a 'promising' 'improvement' when everything else failed) https://t.co/kiqrbd5Ulw https://t.co/NgDg4Q0DL4 https://t.co/UjktVHqy8Y
$SAVA it's incredibly cavalier for some smart money to take a flier on simufilam because... 'gosh, just look at potential upside and FDA won't take action because any misdeeds occured in the early phases and drug has proven safe so far.' But guess what: the late stage trials…
On the neuro side - $SAVA - am skeptical w/ all these Alz drugs to begin with - long timers know the story behind so I won't repeat - $LBPH - strange trade on Friday - it's an epilepsy play - long timers again know my bias favoring this area within neuros - early phase data has…