Wasatch Biolabs is investing in nanopore sequencing technology for clinical testing and research services, highlighting the method's ability to perform comprehensive multiomics analysis. Nanopore sequencing, as detailed by various sources, enables the analysis of single nucleotide variations (SNVs), structural variations (SVs), copy number variations (CNVs), short tandem repeats (STRs), haplotyping, and methylation, as well as RNA isoforms in one platform. This technology is also being used to probe chromatin accessibility with small molecule DNA intercalation, offering insights into chromatin structure through the detection of modifications like angelicin in DNA, which can be identified from Nanopore current signal data using neural network models trained on chromatin-free DNA.
Nanopore sequencing of the angelicin-modified DNA is possible and allows analysis of long single molecules w/ distinct chromatin structure. The angelicin modification can be detected from the Nanopore current signal data using a neural network model trained on chromatin-free DNA.
Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing https://t.co/VggDI9aduO https://t.co/qprsEerDS4
Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing https://t.co/lQeRyrcEVO #biorxiv_genomic
Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing https://t.co/neYgcKWdrU #bioRxiv
Single-cell ATAC-seq: strength in numbers | Genome Biology | Full Text https://t.co/pFZqiCxaq2
Unlock the full potential of multiomics without the complexity. Nanopore sequencing offers a comprehensive analysis. Dive into the details of SNVs, SVs, CNVs, STRs, haplotyping, & methylation alongside RNA isoforms, in one platform. Learn more: https://t.co/LjOlQZaWfu #WYMM https://t.co/Ay4k0Gjd84
Wasatch Biolabs Bets on Nanopore Sequencing for Clinical Testing, Research Services https://t.co/un09UyMAFb