Researchers from UCLA and Penn, led by LTULab and mikejg84, have identified over 200,000 new gene transcripts in the developing human brain, potentially enhancing understanding of brain maturation and genetic risks for neuropsychiatric disorders. The study, published in ScienceMagazine, explores single-cell genomics, regulatory networks, and cell-to-cell communication in 388 human brains. Other studies in ScienceMagazine and ScienceAdvances delve into gene regulation during neurodevelopment, cell-type changes across lifespan and brain disorders, and cell-type proportion shifts in Alzheimer's disease, schizophrenia, and autism.
Excited to share our #SingleCell #PSYCHENCODE24 study, reporting 470k cells in 27 cell types across 140 individuals from 2 #schizophrenia cohorts https://t.co/O93oMPauid
"Significant impact on the growth of brain cells and improving memory." @billmurphyjr https://t.co/AmoooEsgbm
New study conducted by our lab in collaboration with #PsychENCODE has made significant discoveries linking genetic variants to genes and cell types in human brain. #psychencode24 For more details, refer to our original thread: https://t.co/dz0P7ddEWP https://t.co/WT4QDUGJl4
How do #brain #celltypes change with age, sex & brain disorders across lifespan? Out now in @ScienceAdvances, @doyouseewhy combines #SingleCell #methylation and #Genetics across 1270 brains, finding ⬇️endo cells mediates #Alzheimers risk. #PsychENCODE24 https://t.co/xpB21ulCsm
New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Major developmental shifts in #genetic reg., New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24 https://t.co/COilXdAAAh
How do quantities of brain cells – the fundamental unit of life – differ in Alzheimer’s disease, schizophrenia and autism? Our work on cell-type proportion shifts using methylomics is just out in @ScienceAdvances #PsychENCODE @mikejg84 @DanielVo10 https://t.co/jQDDlQKPau 🧵
Excited to share our #SingleCell dissection of #Schizophrenia, out in @ScienceMagazine today, reporting 470k cells in 27 cell types across 140 individuals from 2 cohorts, revealing key insights on #ExcitatoryNeurons, #NeuroDevelopment, #Synapses, #1Cmetabolism, #Genetics,… https://t.co/EInzSURSqm https://t.co/BJCngnLY1q
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain https://t.co/Fe5b3lrV6x https://t.co/64bWyBbYWk
New paper on single-cell genomics & regulatory networks for 388 human brains just out in @ScienceMagazine. Neat stuff on single-cell QTLs, cell-to-cell communication, & DL models simulating drug effects (https://t.co/4paOy63nOu) #PsychENCODE24 https://t.co/Y2r3BWoicI
New paper on the single-cell genomics & regulatory networks for 388 human brains just out in @ScienceMagazine. Neat stuff on single-cell QTLs, cell-to-cell communication & DL models simulating drug effects https://t.co/PZTUeaVE8B
Researchers @UCLA & @Penn led by @LTULab & @mikejg84 have uncovered over 200,000 new gene transcripts in the developing human brain. Their findings could enhance our understanding of brain maturation & genetic risks for neuropsychiatric disorders. https://t.co/ZSfyF8k2Rr https://t.co/C5W91jWp9K
This week in Science, @ScienceAdvances, and @ScienceTM, the #PsychENCODE Consortium lay out findings based on examining human brains at the single-cell level. Learn more: https://t.co/O1NCcM6zV8 #DecodingTheBrain https://t.co/mp8cvbd05M