A recent study on gene expression in African Americans has revealed ancestry-related differences impacting immune and vascular genes, potentially influencing neurological disease risk. The research showcases the significance of diverse biobanks in assessing the genetic ancestry's impact on brain disorders like Alzheimer's.
“Ancestry-associated differentially expressed genes (DEGs), transcripts and gene networks, while notably not implicating neurons, are enriched for genes related to the immune response and vascular tissue and explain up to 26% of heritability for ischemic stroke, 27% of… https://t.co/nlWHSZnsTM
My problem with the brain gene expression ancestry study isn't even specific to that study, but common to a large share of modern genomics studies: this is peak Garden of Forking Paths. 🧵
Interesting paper looking at brain gene expression differences in African Americans and finding enrichments related to immune response but not neurological function. [Benjamin et al. Nat Neuro; https://t.co/YJzWfxWQ57].
A study of gene expression in admix Black Americans reported in @NatureNeuro shows genetic ancestry-linked differences impacting immune and vascular genes and potentially influencing neurological disease risk. https://t.co/kM2stW5MJW https://t.co/xhykqBveuN
Study Reveals Ancestry-Related Differences in Postmortem Brain Gene Activity https://t.co/37pbr0nIPf https://t.co/1iRkD58yge
Study of Brain Related Genes Showcases Value of Diverse Biobanks Diverse tissue-based biobank helps assess the impact of genetic ancestry on brain disorders like Alzheimer's in African Americans. Read more: https://t.co/T2p1QUTeLW https://t.co/GnGKEoo5Rt