A study reveals that the lifetime risk of atrial fibrillation has risen from one in four to one in three over the past two decades, with two in five individuals with the condition likely to develop heart failure. Another study highlights the impact of education polygenic scores on rare developmental delay genes, suggesting the environment plays a significant role. Additionally, a new heart disease calculator developed by the University of Oxford could help identify high-risk patients missed by current tools, potentially saving lives.
Genetic risk shouldn't be considered in isolation. Our work led by @buutrg shows how clinical risk factors and a coronary artery disease polygenic risk score interact to optimally inform coronary artery disease risk. https://t.co/8Lb65Y0uFF @MedCellPress https://t.co/tKnE7VgnG3 https://t.co/7XjJGvtFlu
Evidence for why a polygenic risk score for coronary artery disease, in conjunction with clinical risk factors, provides useful individualized risk assessment https://t.co/g3dE6jitGe @pnatarajanmd @buutrg @Cell_Med https://t.co/PQSWses6SJ
Tufts Medicine's @l_trinquart is senior author on a new study showing 2 out of 5 patients will develop heart failure after atrial fibrillation diagnosis. The findings could be used to inform future changes to atrial fibrillation guidelines: https://t.co/EVPZjfspgq @tuftsctsi
New #heartDisease calculator could save lives by identifying #high-riskPatients missed by current tools @UniofOxford @NatureMedicine https://t.co/VT7BJSKdhk
Interesting study looking at how common education polygenic scores modify the effect of rare developmental delay genes. Given that the EA PGS is actually 2/3rds dynastic environment (or stratification), this suggests that environment could be a substantial compensatory force. https://t.co/mPzAzfqU9M
The lifetime risk of atrial fibrillation has increased from one in four to one in three over the past two decades, finds study. Among those with the condition, two in five are likely to develop heart failure over their remaining lifetime @nicklas_vinter https://t.co/fqpznNgf7x