Recent studies and expert discussions have highlighted the complex mechanisms by which severe COVID-19 infections can lead to heart damage, even in the absence of direct viral infection of the heart tissue. Researchers, including those from Charité – Universitätsmedizin Berlin (@ChariteBerlin) and Massachusetts General Hospital (@MGH_RI), led by @JanaGrune and @MatthiasNahrend, have found that severe COVID-19 can trigger myocarditis through the activation of heart macrophages, without the virus being present in the heart. This process involves an increase in total cardiac macrophage counts and a higher proportion of CCR2+ macrophages, which are indicative of an inflammatory response. The findings, published in journals such as Circulation and featured in discussions by experts like Eric Topol and Dr. Bagai, underscore the virus's ability to cause cardiomyopathy by eliciting inflammatory responses in the heart. This inflammation can occur through both ACE2-dependent and -independent pathways of viral entry into cells, affecting viral replication and the inflammatory response during infection, as discussed in @NatureCellBio. The implications of these findings extend to understanding the progression of cardiac injury in patients, including children with multisystem inflammatory syndrome associated with SARS-CoV-2 (SARSCoV2) infection.
ACE2-dependent & -independent SARSCoV2 entries dictate viral replication & inflammatory response during infection. ACE2-dependent & -independent entries of SARSCoV2 in epithelial cells vs myeloid cells dictate viral replication, inflammatory responses, https://t.co/vGnkfDGaCu
Frontiers | Cardiac injury progression in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection: a review https://t.co/xYJzBnD6LU
ACE2-dependent and -independent SARSCoV-2 entries dictate viral replication & inflammatory response during infection. ACE2-dependent & -independent entries of SARSCoV2 in epithelial cells vs myeloid cells dictate viral replication, inflammatory responses, https://t.co/vGnkfDGaCu
How Covid can change from a high viral replication, low inflammatory state to the opposite https://t.co/L7LiXJG9Or @NatureCellBio https://t.co/4OC9zJUqUf
Severe lung infection during COVID-19 can cause damage to the heart Severe infections, such as SARS-CoV-2, can cause problems in other organs such as the heart. https://t.co/DsBQSGrzPK 1/7
COVID-induced lung infection linked to heart damage The lung infection caused by COVID-19 increased cardiac macrophages. https://t.co/8tVhAFAPLc https://t.co/SlJHNJZWQU
Virus-Induced ARDS Causes Cardiomyopathy Thro Eliciting Inflammatory Responses in Heart; SARSCoV2⬆️total cardiac macrophage counts; ⬆️ proportion of CCR2+ (C-C chemokine receptor type 2 positive) macrophages, SARSCoV2 & virus-free lung injury triggered https://t.co/FyMfU1SiNL
COVID-19 can damage the heart in patients with Acute Respiratory Distress Syndrome) without directly infecting heart tissue. Read more: https://t.co/cjAROjKBZX
Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart | Circulation https://t.co/BW3h3rqHnr
How severe Covid leads to myocarditis without virus in the heart: the role of activated heart macrophages https://t.co/osW3Xe9sHo @JanaGrune @ChariteBerlin @MatthiasNahrend @MGH_RI and colleagues https://t.co/Muc4ZwnZjw