Recent studies highlighted in @Nature and discussed across several platforms have uncovered a significant mechanism by which early-stage colorectal cancer cells evade the immune system. Researchers from @kochinstitute, @MIT, and @harvardmed, including @ohyilmaz and @JudithAgudo1, have pinpointed the SOX17 gene as a key player in this process, enabling these cells to become 'invisible' to immune defenses. This discovery was made using an organoid colon cancer model and represents a critical step forward in understanding cancer's early interactions with the immune system. The findings, also discussed in @natimmunol and @JExpMed, could have profound implications for future cancer detection and treatment strategies.
Colon Cancer Traced to Cells That Activate Immune-Escape Genes Scientists have found that early-stage colorectal cancer cells recruit the SOX17 gene to essentially become invisible to the immune system. Learn more: https://t.co/q2HKQCjnk4 https://t.co/0oISmKfVMi
Nature research paper: SOX17 enables immune evasion of early colorectal adenomas and cancers https://t.co/kDEqL6SvJV
Researcher discusses turbocharging #CRISPR to understand how the immune system fights cancer @harvardmed @natimmunol @JExpMed https://t.co/LbDPeTGTrt
We've known how advanced cancer overrides our immune system. Now a new @Nature report on how early-stage, pre-cancerous cells can do that using an organoid colon cancer model https://t.co/GznNPkTIji @kochinstitute @ohyilmaz @JudithAgudo1 https://t.co/TCqWcjyAz5
How early-stage #cancer cells hide from the #immuneSystem @MIT @nature https://t.co/aoXRkbSSy3