Researchers have introduced innovative techniques like GoT-ChA and an Epigenetic Editing toolkit to study genotypes and chromatin accessibility in single cells. These tools enable precise programming of chromatin modifications for studying gene expression and somatic mutations.
New Tech Unlocks Secrets of Gene Regulation and Epigenetics Researchers developed an epigenome editing platform that allows for the targeted application of epigenetic modifications anywhere in the genome. This innovative system uses CRISPR technology to alter chromatin marks,… https://t.co/jnTEZXZx75
GoT–ChA: Mapping genotypes to chromatin accessibility profiles in single cells https://t.co/ayB4TVd6mH https://t.co/SnofkBFOwQ
Building custom epigenomes🏗️ Hot off the press @NatureGenet from the @hackettlab: an #EpigeneticEditing toolkit to precisely program key chromatin modifications onto the genome and systematically test their impact on gene expression. Massive congrats to @CristinaPolica4! 🔥 1/ https://t.co/kXDAlCIkNf
A high-throughput single-cell multi-omics technique GoT–ChA enables simultaneous genotyping and chromatin accessibility profiling to study how somatic mutations disrupt epigenetic landscapes in clonal expansions.https://t.co/n3oelHmKvy #NBThighlight
Nature research paper: Mapping genotypes to chromatin accessibility profiles in single cells https://t.co/vMy3NiUH9E